NCT06853938 Optimizing Transhumeral Osseointegration Prosthesis Control
| NCT ID | NCT06853938 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Alberta |
| Condition | Transhumeral Amputation |
| Study Type | INTERVENTIONAL |
| Enrollment | 5 participants |
| Start Date | 2025-09-01 |
| Primary Completion | 2028-06-14 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 5 participants in total. It began in 2025-09-01 with a primary completion date of 2028-06-14.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Upper limb amputation above the elbow results in a significant loss of function. There have been many advancements in surgery and prosthetic devices to restore arm function, but many people still reject upper limb prostheses. This is due to difficulties with how the socket fits and poor control of the device. Above-elbow prostheses are particularly challenging to use for several reasons. The socket must go all the way into the shoulder for stability. To hold the prosthesis onto the remaining arm, there needs to be a strap across the chest and shoulder. The prosthesis can be heavy, and the socket can slip or move around. This makes it hard to use muscle signals in the residual limb to control advanced prosthetic devices. People with limb loss are interested in advanced prostheses to use them reliably for day-to-day activities. Bone-anchored prostheses (BAPs) are a new approach. They are for people with upper limb loss who can't use socket prostheses. The surgery involves putting a titanium rod into the remaining bone, which, over time, joins with the bone. This implant extends through the skin. It enables the direct attachment of the prosthetic parts (like the elbow and hand). With BAPs, there is no need for a socket. Also, there is a well-known surgery called "Targeted muscle reinnervation" (TMR). It improves the number of arm muscle control signals. These signals are used to control myoelectric prostheses. However, after both these surgeries, there is a lack of research that shows how best to train the muscle signals to use an advanced myoelectric arm and little evidence on what factors actually improve in a person's day-to-day life when using such a prosthesis. This study aims to implement an enhanced muscle training protocol and fitting with a myoelectric (muscle signal-controlled) device after receiving OI and TMR for above-elbow amputation, and to evaluate the outcomes over time. The goal is to understand whether these advanced prostheses improve prosthesis use and function in daily life.
Eligibility Criteria
Inclusion Criteria: Individuals with transhumeral amputation who: 1. are between 18 and 65 years old, 2. have been scheduled to undergo osseointegration by the Alberta Limb Osseointegration Program. 3. demonstrate adequate pain-free shoulder range of motion to perform the required tasks and have potential muscle signals for myoelectric control to be able to undertake the muscle signal training 4. willing to undergo all of the study procedures and follow-up. Exclusion Criteria: Individuals who: 1. are unable to comply with treatment or follow-up processes, 2. are unable to understand English sufficiently to provide full informed consent. 3. have shoulder pathology on the side of the amputation (arthritis, adhesive capsulitis, chronic rotator cuff, or musculoskeletal dysfunction) that would negatively affect the ability to perform the training and functional assessments, 4. have insufficient muscle signals to operate a myoelectric prosthesis
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06853938 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Transhumeral Amputation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06853938 currently recruiting?
Yes, NCT06853938 is actively recruiting participants. Contact the research team at jhebert@ualberta.ca for enrollment information.
Where is the NCT06853938 trial being conducted?
This trial is being conducted at Edmonton, Canada, Edmonton, Canada.
Who is sponsoring the NCT06853938 clinical trial?
NCT06853938 is sponsored by University of Alberta. The trial plans to enroll 5 participants.