NCT05381038 Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI
| NCT ID | NCT05381038 |
| Status | Recruiting |
| Phase | Phase 1, Phase 2 |
| Sponsor | National University Hospital, Singapore |
| Condition | Solid Tumor |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2023-02-13 |
| Primary Completion | 2026-10-04 |
Trial Parameters
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Brief Summary
This pilot feasibility study aims to set the foundation to investigate the applicability of QPOP drug selection followed by CURATE.AI-guided dose optimisation of the selected azacitidine combination therapy for solid tumours using CURATE.AI within the current clinical setting. QPOP will identify drug interactions towards optimal efficacy and cytotoxicity from the pre-specified drug pool based on ex vivo experimental data from the individual participant's tissue sample model. With these drug interactions, QPOP will identify the optimal drugs for the specific participant whose biopsy provided the cells for the ex vivo experimentation. Subsequently, CURATE.AI will be used to guide dosing for the selected combination therapy for that participant. Individualised CURATE.AI profiles will be generated based on each participant's response to a set of drug doses. Subsequently, the personalised CURATE.AI profile will be used to recommend the efficacy-driven dose. CURATE.AI will operate only within the safety range for each drug pre-specified for each participant. This pilot feasibility study will inform the investigators on the logistical and scientific feasibility of performing a large-scale randomised controlled trial (RCT) with the selected azacitidine combination therapy regimens and response markers. A secondary objective is to collect toxicity and efficacy data using established and exploratory response markers within and in-between cycles as exploratory outcomes.
Eligibility Criteria
Inclusion Criteria: 1. Males and females ≥ 21 years of age. 2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2. 3. Patients must meet the following clinical laboratory criteria within 21 days of starting treatment: 1. Absolute neutrophil count (ANC) ≥ 1,000/mm3 and platelet ≥ 50,000/mm3 2. Total bilirubin ≤ 1.5 x the upper limit of the normal range (ULN). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN of ≤ 5 ULN if involvement of the liver. 3. Calculated creatinine clearance ≥ 30 mL/min or creatinine \< 1.5 x ULN. 4. Diagnosed with breast or gastric cancer, where docetaxel, paclitaxel or irinotecan is indicated for palliative therapy. 5. Patients who have undergone QPOP drug screen (e.g. under QGAIN (2019/00924) or NGAIN trial (2021/00009) where the drug screen indicated potential benefit of combining azacitidine with taxane or irinotecan. 6. Patients must have raised response marker above upper limit of local laboratory normal (e.g