NCT07122336 Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
| NCT ID | NCT07122336 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Chest Hospital |
| Condition | Persistent Atrial Fibrillation |
| Study Type | INTERVENTIONAL |
| Enrollment | 384 participants |
| Start Date | 2025-07-16 |
| Primary Completion | 2025-12-31 |
Trial Parameters
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Brief Summary
The design of this study is an intervention, randomized, controlled study and contains three randomized groups：（1）PVI group；（2）PVI+PWI group;（3）PVI+PWI+EGM group.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥18 years 2. First-time ablation for persistent atrial fibrillation (PsAF) 3. Persistent AF definition: Sustained episodes lasting ≥7 days but ≤3 years (including episodes requiring pharmacologic or electrical cardioversion after ≥7 days) 4. Symptomatic AF with intolerance to at least one antiarrhythmic drug (AAD) 5. Documented PsAF episode: At least one recorded PsAF episode within the last 2 years prior to enrollment, confirmed by: ECG,Holter monitorin, Loop recorder, Telemetry, Transtelephonic monitoring (TTM),Implantable device 6. Ability and willingness to provide written informed consent 7. Compliance with all study follow-up requirements Exclusion Criteria: 1. Paroxysmal AF: Episodes lasting \<7 days (or requiring pharmacologic/electrical cardioversion \<7 days) 2. Long-standing persistent AF: Continuous AF duration \>3 years 3. No prior attempt/pursuit of cardioversion or sinus rhythm maintenance 4. Contraindications to systemic anticoagulation 5. Pre
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