NCT06879769 Optimization of Patient Preparation and Imaging Techniques for Cardiac CT
| NCT ID | NCT06879769 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Karolinska University Hospital |
| Condition | Coronary Computed Tomography Angiography |
| Study Type | INTERVENTIONAL |
| Enrollment | 240 participants |
| Start Date | 2021-01-01 |
| Primary Completion | 2026-01-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 240 participants in total. It began in 2021-01-01 with a primary completion date of 2026-01-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to compare four different methods of reducing heart rate before cardiac imaging. The diagnostic imaging technique used in this study is called Computed Tomography (CT) of the coronary vessels (CCTA). Globally, approximately one-third of patients experience heart-related conditions. Because the heart is a moving organ, imaging presents challenges. A higher heart rate requires increased scanning power, which results in more images and, in some cases, higher radiation exposure that may be harmful. To address this issue, beta-blocker medication is administered before the examination to lower the heart rate. This medication can be given orally, intravenously, or both. While this approach is effective, the most optimal method remains uncertain. The objectives of this study are: * To determine whether oral administration of beta-blockers is as effective as intravenous administration in maintaining a stable heart rate during CT imaging. * To assess whether listening to music during the procedure improves patient comfort and overall experience. Participants will: * Be randomly assigned to one of four groups: * One group will receive beta-blocker medication orally. * Another group will receive beta-blocker medication intravenously. * One group will listen to music during the procedure. Participants will report their sensations and experiences before, during, and after the examination. The study investigators will compare the effectiveness of oral and intravenous beta-blockers, as well as the impact of music, in terms of: * Heart rate stability and reduction. * Participant-reported comfort and overall experience.
Eligibility Criteria
Inclusion Criteria: * Participant with a preexisting referral for a Cardiac CT examination * Age 18 years or older Exclusion Criteria: * Age under 18 years * Atrial fibrillation * Pacemaker * Participation in clinical drug trials * Contraindications to beta-blockers * Severe medical conditions * Challenges in comprehending study information * Pregnancy
Contact & Investigator
Anders Svensson-Marcial, PhD
PRINCIPAL INVESTIGATOR
Karolinska University Hospital, Department of Clinical Science, Intervention and Technology
Frequently Asked Questions
Who can join the NCT06879769 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Computed Tomography Angiography. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06879769 currently recruiting?
Yes, NCT06879769 is actively recruiting participants. Contact the research team at aziza.adem@ki.se for enrollment information.
Where is the NCT06879769 trial being conducted?
This trial is being conducted at Stockholm, Sweden.
Who is sponsoring the NCT06879769 clinical trial?
NCT06879769 is sponsored by Karolinska University Hospital. The principal investigator is Anders Svensson-Marcial, PhD at Karolinska University Hospital, Department of Clinical Science, Intervention and Technology. The trial plans to enroll 240 participants.