Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
Trial Parameters
Eligibility Fast-Check
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Brief Summary
Standard Heparin management, based on total body weight, is not well established for obese patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). The purpose of this study is to assess the safety and efficacy of using lean body mass (LBM) to determine pump flow rate and/or Heparin dosage in obese patients undergoing CPB.
Eligibility Criteria
Inclusion Criteria: * Obese patients (BMI ≥ 30kg/m2) * Planned cardiac surgery * Age ≥ 18 years Exclusion Criteria: * Permanent pacemaker * Known intolerance to protamine * Known or suspected allergy to the used antifibrinolytic agent * Refusal to receive blood products * Planned off pump coronary artery bypass * Planned peri-operative use of desmopressin * Known Heparin-induced thrombocytopenia * Known deficiency in protein C, protein S, antithrombin or homozygous factor V Leiden * Known congenital bleeding disorders * Current endocarditis * Planned hypothermic circulatory arrest (\<28C) * Two or more cardiac surgery procedures * Emergency cardiac surgery procedures (medically required within 24hours of presenting with acute symptoms) * Planned CPB priming with red blood cells * Any known autoimmune disease * Any history of stroke or non-coronary thrombotic disorders including deep venous thrombosis and pulmonary embolism * Significant (≥50%) carotid artery stenosis * Patient dosed wi