NCT07864155 Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
| NCT ID | NCT07864155 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Malatya Egitim Ve Arastirma Hastanesi |
| Condition | Thyroidectomy |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2026-04-01 |
| Primary Completion | 2027-01-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 110 participants in total. It began in 2026-04-01 with a primary completion date of 2027-01-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy. Opioid-based anesthesia is commonly used during surgery, but opioids may be associated with adverse effects such as nausea, vomiting, respiratory depression, hyperalgesia, and increased postoperative opioid use. Opioid-free anesthesia uses non-opioid medications as part of a multimodal strategy to provide intraoperative analgesia. The main aim of this prospective randomized study is to evaluate whether opioid-free anesthesia changes the perioperative oxidative stress response compared with opioid-based anesthesia. Oxidative stress will be assessed using serum biomarkers, including native thiol, total thiol, disulfide, total antioxidant status, total oxidant status, and oxidative stress index. Eligible patients will be randomly assigned to receive either opioid-free anesthesia or fentanyl-based opioid anesthesia. Blood samples will be collected before anesthesia induction, 30 minutes after extubation, and 24 hours after surgery. The study will also compare postoperative pain scores, rescue analgesic requirement, postoperative nausea and vomiting, recovery characteristics, and intraoperative hemodynamic variables between the two anesthesia strategies.
Eligibility Criteria
Inclusion Criteria: * Adult patients aged 18 to 65 years * Scheduled for elective thyroidectomy * American Society of Anesthesiologists physical status I-II * Euthyroid status, defined as thyroid-stimulating hormone, free thyroxine, and free triiodothyronine levels within the reference range * Able to understand the study procedures and provide written informed consent Exclusion Criteria: * Uncontrolled advanced systemic disease, including advanced cardiac, pulmonary, renal, or hepatic failure * Active infection * Use of high-dose antioxidant supplementation within the last month * Widespread inflammation related to malignancy * Known severe allergy or contraindication to any study medication * Refusal to participate in the study
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07864155 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Thyroidectomy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07864155 currently recruiting?
Yes, NCT07864155 is actively recruiting participants. Contact the research team at leman.delen@ozal.edu.tr for enrollment information.
Where is the NCT07864155 trial being conducted?
This trial is being conducted at Malatya, Turkey (Türkiye).
Who is sponsoring the NCT07864155 clinical trial?
NCT07864155 is sponsored by Malatya Egitim Ve Arastirma Hastanesi. The trial plans to enroll 110 participants.