NCT07673185 Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
| NCT ID | NCT07673185 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Al-Azhar University |
| Condition | Periodontal Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2025-01-15 |
| Primary Completion | 2026-07-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2025-01-15 with a primary completion date of 2026-07-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
Eligibility Criteria
Inclusion Criteria: * \- Male or female smokers aged 30 to 50 years. * Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification. * Probing pocket depth (PPD) ≥ 5 mm. * Clinical attachment loss (CAL) ≥ 5 mm. * Presence of at least 20 natural teeth. * Willing and able to provide written informed consent. Exclusion Criteria: * \- Systemic diseases affecting periodontal health. * Pregnancy or lactation. * Periodontal treatment within the previous 6 months. * Use of antibiotics or anti-inflammatory drugs within the previous 6 months. * Allergy or hypersensitivity to omega-3 fatty acids or aspirin. * Long-term anticoagulant therapy. * History of gastric ulcer or bleeding disorders. * Participation in another clinical trial within the previous 3 month
Contact & Investigator
naglaa M EL wakeel, professor
PRINCIPAL INVESTIGATOR
Faculty of Dental Medicine for Girls, Al-Azhar University
Frequently Asked Questions
Who can join the NCT07673185 clinical trial?
This trial is open to participants of all sexes, aged 30 Years or older, up to 50 Years, studying Periodontal Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07673185 currently recruiting?
Yes, NCT07673185 is actively recruiting participants. Contact the research team at alaahesham419@gmail.com for enrollment information.
Where is the NCT07673185 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07673185 clinical trial?
NCT07673185 is sponsored by Al-Azhar University. The principal investigator is naglaa M EL wakeel, professor at Faculty of Dental Medicine for Girls, Al-Azhar University. The trial plans to enroll 40 participants.