NCT07658365 Olfactory Transcranial Focused Ultrasound
| NCT ID | NCT07658365 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of South Carolina |
| Condition | Healthy |
| Study Type | INTERVENTIONAL |
| Enrollment | 28 participants |
| Start Date | 2026-10-01 |
| Primary Completion | 2028-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 28 participants in total. It began in 2026-10-01 with a primary completion date of 2028-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults. Participants undergo sham and active tFUS targeting the amygdala (AMYG) and ventral striatal olfactory tubercle (VSOT) in a within-subject, randomized, sham-controlled crossover design. Outcomes include subjective odor ratings and objective neurophysiological and behavioral indices of odor valence processing. This research is exploratory and mechanistic in nature and is not intended to evaluate clinical safety or therapeutic efficacy.
Eligibility Criteria
Inclusion Criteria: * Age 18-65 years * Healthy adult volunteers * Normal olfactory function (Sniffin' Sticks total TDI ≥ 30.75) * Ability to provide informed consent * English fluency sufficient for task completion Exclusion Criteria: * MRI or tFUS contraindications (e.g., metal implants, claustrophobia, pregnancy) * Sinonasal conditions affecting airflow or smell * Current use of medications that alter olfaction * Positive urine drug screen
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07658365 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Healthy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07658365 currently recruiting?
Yes, NCT07658365 is actively recruiting participants. Contact the research team at cashni@musc.edu for enrollment information.
Where is the NCT07658365 trial being conducted?
This trial is being conducted at Charleston, United States.
Who is sponsoring the NCT07658365 clinical trial?
NCT07658365 is sponsored by Medical University of South Carolina. The trial plans to enroll 28 participants.