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Recruiting NCT05364125

Olfactory Training on Smell Dysfunction Patients in HK

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Plain-language summary for patients

Trial Parameters

Condition Olfaction Disorders
Sponsor Pamela Youde Nethersole Eastern Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 80
Sex ALL
Min Age 18 Years
Max Age 70 Years
Start Date 2022-07-01
Completion 2027-06-30
Interventions
Olfactory TrainingControl

Eligibility Fast-Check

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Brief Summary

* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. * Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery * Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases. * Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries. * Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study. * However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.

Eligibility Criteria

Inclusion Criteria: * Olfactory dysfunction \> 6 months and \< 5 years Exclusion Criteria: * History of significant head injury (fracture, ICH) * History of brain surgery * History of nasal surgery * Active nasal disease * Active neurological disease * Poor premorbid status/ non-communicable patients * Mentally incompetent patients * \<18 years' old * Pregnancy * Hypersensitivity to the aromatic substance.

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