NCT07374692 Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors
| NCT ID | NCT07374692 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Cancer Institute (NCI) |
| Condition | Recurrent CNS Tumors |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2026-02-04 |
| Primary Completion | 2030-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2026-02-04 with a primary completion date of 2030-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background: Primary central nervous system (CNS) tumors grow in the brain and spinal cord. These tumors are rare, but they are difficult to treat and often fatal. SmartMatch is a new technology that tries to help find the best medicines for the particular tumor by testing how small pieces of surgically removed tumor tissue react to different drugs. The study team wants to see if SmartMatch can complete the analysis and generate a report within 21 days from the time of the surgery. Objective: To better understand CNS tumors so doctors can find better ways to treat them in the future. Eligibility: People aged 15 years and older with recurrent CNS tumors. Patient must already be scheduled for a surgery for the tumor at the NIH. Design: The study team will collect a small amount of tumor samples during the planned surgery. They may also use tumor samples from previous procedures. No new or additional procedures will be done for the purpose of this study. The tumor samples will be sent to a lab for SmartMatch analysis. Once completed, the results will be shared with the patient and his/her local doctor. Together they can decide whether to incorporate the results into the treatment plan. It is important to know that the results may or may not be helpful. There will only be one blood test for research. Blood and tissue samples collected may be used for additional analysis. Tumor tissue may be used to grow additional samples for further study. Participants will receive a pathology diagnosis and mutation profile generated by pathologists who specialize in CNS tumors. The study team will seek updates on participant's health approximately every 6 months for 3 years. Tumor samples may also be collected from any additional surgery done at NIH during this time....
Eligibility Criteria
* INCLUSION CRITERIA * Participants must have advanced CNS tumors confirmed by a documented pathology report, including: * recurrent isocitrate dehydrogenase (IDH)-wild-type high-grade glioma * recurrent IDH-mutant gliomas * other recurrent CNS tumors * Participants must have been scheduled for a brain tumor biopsy or resection. Note: Scheduled brain tumor biopsy or resection must be at least 6 months after any previous radiation therapy, if applicable. All procedures are planned to take place at NIH. * Age \>= 15 years. * Ability of participant, parent/guardian, or Legally Authorized Representative (LAR) to understand and sign a written informed consent document. EXCLUSION CRITERIA None.
Contact & Investigator
Jing Wu, M.D.
PRINCIPAL INVESTIGATOR
National Cancer Institute (NCI)
Frequently Asked Questions
Who can join the NCT07374692 clinical trial?
This trial is open to participants of all sexes, aged 15 Years or older, up to 120 Years, studying Recurrent CNS Tumors. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07374692 currently recruiting?
Yes, NCT07374692 is actively recruiting participants. Contact the research team at christine.mcgowan@nih.gov for enrollment information.
Where is the NCT07374692 trial being conducted?
This trial is being conducted at Bethesda, United States.
Who is sponsoring the NCT07374692 clinical trial?
NCT07374692 is sponsored by National Cancer Institute (NCI). The principal investigator is Jing Wu, M.D. at National Cancer Institute (NCI). The trial plans to enroll 80 participants.