NCT07794800 Observational Cohort Study on Ocular Chronic Graft-Versus-Host Disease
| NCT ID | NCT07794800 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ruijin Hospital |
| Condition | Chronic Graft Versus Host Disease in Eye |
| Study Type | OBSERVATIONAL |
| Enrollment | 340 participants |
| Start Date | 2026-06-01 |
| Primary Completion | 2030-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 340 participants in total. It began in 2026-06-01 with a primary completion date of 2030-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is a multicenter, prospective, observational cohort study designed to enroll a total of 340 patients undergoing allogeneic hematopoietic stem cell transplantation. Through comprehensive evaluations by hematology departments, ophthalmology departments, and patient-reported outcomes, the study aims to assess patient-reported outcomes, overall incidence, risk factors, and other clinical outcomes in patients with chronic ocular graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Eligibility Criteria
Inclusion Criteria: * Age ≥14 years, both genders eligible; * First allogeneic hematopoietic stem cell transplantation; * 100 days post-transplantation, with donor hematopoietic stem cell engraftment confirmed; * The subject or their legally authorized representative has provided full informed consent, signed the informed consent form, and is willing to complete subsequent follow-up visits Exclusion Criteria: * Preexisting moderate-to-severe ocular surface disease prior to transplantation; * Active ocular infection; * Presence of other ocular conditions that, in the opinion of the ophthalmologist, may significantly affect the diagnosis of chronic ocular graft-versus-host disease, the evaluation of ocular surface parameters, or the completion of long-term follow-up; * Patients with active hematologic malignancies.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07794800 clinical trial?
This trial is open to participants of all sexes, aged 14 Years or older, studying Chronic Graft Versus Host Disease in Eye. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07794800 currently recruiting?
Yes, NCT07794800 is actively recruiting participants. Contact the research team at jch12191@rjh.com.cn for enrollment information.
Where is the NCT07794800 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT07794800 clinical trial?
NCT07794800 is sponsored by Ruijin Hospital. The trial plans to enroll 340 participants.