NCT06996834 Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia
| NCT ID | NCT06996834 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Assiut University |
| Condition | Community-acquired Pneumonia |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2026-07-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2025-07-01 with a primary completion date of 2026-07-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute exacerbations of community-acquired pneumonia (CAP) accompanied by hypoxemic respiratory failure. The primary focus is on assessing treatment failure within 48 hours, defined as the need for intubation or death. Secondary outcomes include evaluations of gas exchange parameters, patient comfort levels, duration of ICU stay, and 28-day mortality rates.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * Clinical and radiographic diagnosis of CAP * Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen/fraction of inspired oxygen ratio (PaO₂/FiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25/min * Informed consent obtained Exclusion Criteria: * Hemodynamic instability requiring vasopressors * Altered mental status Glasgow Coma Scale (GCS \< 13) * Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery) * Do-Not-Intubate (DNI) order
Contact & Investigator
Ahmad M. Shaddad, MD
PRINCIPAL INVESTIGATOR
Assiut University
Frequently Asked Questions
Who can join the NCT06996834 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Community-acquired Pneumonia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06996834 currently recruiting?
Yes, NCT06996834 is actively recruiting participants. Contact the research team at shaddad_ahmad@yahoo.com for enrollment information.
Where is the NCT06996834 trial being conducted?
This trial is being conducted at Asyut, Egypt.
Who is sponsoring the NCT06996834 clinical trial?
NCT06996834 is sponsored by Assiut University. The principal investigator is Ahmad M. Shaddad, MD at Assiut University. The trial plans to enroll 100 participants.