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Recruiting Phase 3 NCT06973785

Non-Narcotic Pain Control After ACL Reconstruction

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Trial Parameters

Condition ACL - Anterior Cruciate Ligament Rupture
Sponsor The Cleveland Clinic
Study Type INTERVENTIONAL
Phase Phase 3
Enrollment 30
Sex ALL
Min Age 15 Years
Max Age 55 Years
Start Date 2025-07-15
Completion 2026-09-30
Interventions
dispense of study drugKetorolac

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Brief Summary

This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses taken and documenting the number of patients with no exposure to any narcotics (take zero oxycodone) after undergoing primary knee ACL reconstruction outpatient surgery.

Eligibility Criteria

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged 15-55 years * Primary Autograft ACL surgery * Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts Exclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for t the duration of the study * Male or female, aged 15-55 years * Primary Autograft ACL surgery * Ability to take oral medication and willingness to patriciate in a virtual 1 and 2 week follow-up pill counts

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