NCT06669299 Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies
| NCT ID | NCT06669299 |
| Status | Recruiting |
| Phase | — |
| Sponsor | IRCCS Ospedale San Raffaele |
| Condition | Ventricular Tachycardia (VT) |
| Study Type | INTERVENTIONAL |
| Enrollment | 51 participants |
| Start Date | 2025-06-12 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 51 participants in total. It began in 2025-06-12 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment strategy. The primary objective is to establish whether a new VT ablation based on NIPS inducibility will reduce the risk of VT recurrence compared to antiarrhythmic drug therapy.
Eligibility Criteria
Inclusion Criteria: * Patients with an implanted ICD (all brands) * Patients who underwent a successful (non-inducibility of any VT) Ventricular Tachycardia Ablation procedure, the "index procedure", supported by EnSite Precision or CARTO 3D mapping systems for the following etiologies: previous MI, myocarditis, ARVD, IDCM. * Induction of monomorphic VT at NIPS 3-7days after a successful index procedure * Age 18 years or more * Able to provide an informed consent to participate to the study and available to respect the assessments described in the protocol. Exclusion Criteria: * Inducible VT after index procedure * Contraindication to anticoagulants * Presence of thrombi * Presence of Mitral and Aortic prosthetic valve * Recent (\<3 months) myocardial infarction or unstable angina or Coronary Artery Bypass * Pregnant or nursing * Ventricular Tachycardia caused by reversible pathology * \< 1 Year life expectancy according to the investigator
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06669299 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ventricular Tachycardia (VT). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06669299 currently recruiting?
Yes, NCT06669299 is actively recruiting participants. Contact the research team at radinovic.andrea@hsr.it for enrollment information.
Where is the NCT06669299 trial being conducted?
This trial is being conducted at Milan, Italy.
Who is sponsoring the NCT06669299 clinical trial?
NCT06669299 is sponsored by IRCCS Ospedale San Raffaele. The trial plans to enroll 51 participants.