NCT06572280 Non-invasive Phrenic Nerve Stimulation in ARDS Patient
| NCT ID | NCT06572280 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Southeast University, China |
| Condition | ARDS, Human |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2024-08-01 |
| Primary Completion | 2024-12-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2024-08-01 with a primary completion date of 2024-12-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.
Eligibility Criteria
Inclusion Criteria: 1. Adult ARDS patients undergoing controlled mechanical ventilation 2. The duration of endotracheal intubation \< 48 hrs Exclusion Criteria: 1. Neurological condition affecting motor neuron or muscle (e.g. ALS) 2. Paralysis of the phrenic nerve 3. Proven or suspected spinal cord injury 4. Conditions that limit diaphragm movement 5. Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator) 6. Patients with implanted medical pumps 7. Pregnancy 8. Patients with skin lesions, infections or strictures in throat/neck area 9. Patients with metallic implants 10. Refusal to sign informed consent
Contact & Investigator
ling liu, phD
PRINCIPAL INVESTIGATOR
Zhongda Hospital
Frequently Asked Questions
Who can join the NCT06572280 clinical trial?
This trial is open to participants of all sexes, studying ARDS, Human. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06572280 currently recruiting?
Yes, NCT06572280 is actively recruiting participants. Contact the research team at 18826401594@163.com for enrollment information.
Where is the NCT06572280 trial being conducted?
This trial is being conducted at Nanjing, China.
Who is sponsoring the NCT06572280 clinical trial?
NCT06572280 is sponsored by Southeast University, China. The principal investigator is ling liu, phD at Zhongda Hospital. The trial plans to enroll 10 participants.