NCT05382585 Newer Therapeutic Targets in Head and Neck Cancers
| NCT ID | NCT05382585 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Banaras Hindu University |
| Condition | Head Neck Cancer |
| Study Type | OBSERVATIONAL |
| Enrollment | 200 participants |
| Start Date | 2017-04-01 |
| Primary Completion | 2027-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 200 participants in total. It began in 2017-04-01 with a primary completion date of 2027-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes: 1. cellular survival and proliferation (e.g., TP53, EGFR, MET, and PIK3CA); 2. cell-cycle control (e.g., CDKN2A and CCND1); 3. cellular differentiation (e.g., NOTCH1); and 4. Adhesion and invasion signaling (e.g., FAT1).7 TP53, EGFR, PIK3CA, CDKN2A, CCND1, and MET participate in several common signaling pathways. Alterations of these genes are most frequently seen in alcohol and tobacco-related HNSCC. However their role in prognostication and selection of therapeutics is not known
Eligibility Criteria
Inclusion Criteria: * Histologically proven cases of primary head and neck cancers. Exclusion Criteria: * Patients under 18 years of age * Pregnant and lactating women * Multiple cancers or patients with cancer of other sites.
Contact & Investigator
Manoj Pandey, MS, PhD
PRINCIPAL INVESTIGATOR
Professor
Frequently Asked Questions
Who can join the NCT05382585 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Head Neck Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05382585 currently recruiting?
Yes, NCT05382585 is actively recruiting participants. Contact the research team at manojpandey66@gmail.com for enrollment information.
Where is the NCT05382585 trial being conducted?
This trial is being conducted at Varanasi, India.
Who is sponsoring the NCT05382585 clinical trial?
NCT05382585 is sponsored by Banaras Hindu University. The principal investigator is Manoj Pandey, MS, PhD at Professor. The trial plans to enroll 200 participants.
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