NCT05283265 Neurophysiological Mechanisms of Language Comprehension
| NCT ID | NCT05283265 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Alabama at Birmingham |
| Condition | Language Disorders |
| Study Type | INTERVENTIONAL |
| Enrollment | 153 participants |
| Start Date | 2022-04-08 |
| Primary Completion | 2026-10-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 153 participants in total. It began in 2022-04-08 with a primary completion date of 2026-10-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators simultaneously record neural activity through intracranial electrodes that are implanted for clinical purposes (see subject populations). At the end of the sentence, the subjects have to indicate how they comprehended the sentence by selecting which of several pictures matches the sentence they just read. Behavioral measures that the investigators record and analyze are their response times to advance to each next word in the sentence, and which picture they chose for each sentence. These behavioral measures are compared against the neural activity simultaneously recorded as they are made. Then, in a later session, the same participants will participate in a task-related stimulation experiment. This follows the exact same design as the recording-only reading experiment, the only difference is that on some trials, at controlled moments during the sentence presentation intracranial electrical stimulation is delivered through adjacent intracranial electrode contacts. The investigators will examine the effect of this stimulation on the subjects comprehension of the sentences measured by their behavior, and on the simultaneously recorded neural activity.
Eligibility Criteria
Inclusion Criteria: * Age 18 and older * Undergoing standard of care stereo Electro Encephalogram (sEEG) or Electro-Corticogram (ECoG) monitoring * Able to competently perform control trials of the task Exclusion Criteria: * Age less than 18 years * Unable to competently perform control trials of the task
Contact & Investigator
Matthew Nelson, PhD
PRINCIPAL INVESTIGATOR
The University of Alabama at Birmingham
Frequently Asked Questions
Who can join the NCT05283265 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Language Disorders. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05283265 currently recruiting?
Yes, NCT05283265 is actively recruiting participants. Contact the research team at matthewnelson@uabmc.edu for enrollment information.
Where is the NCT05283265 trial being conducted?
This trial is being conducted at Birmingham, United States.
Who is sponsoring the NCT05283265 clinical trial?
NCT05283265 is sponsored by University of Alabama at Birmingham. The principal investigator is Matthew Nelson, PhD at The University of Alabama at Birmingham. The trial plans to enroll 153 participants.