NCT07367126 Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
| NCT ID | NCT07367126 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital |
| Condition | Knee Osteoarthristis |
| Study Type | OBSERVATIONAL |
| Enrollment | 102 participants |
| Start Date | 2025-12-20 |
| Primary Completion | 2026-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 102 participants in total. It began in 2025-12-20 with a primary completion date of 2026-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.
Eligibility Criteria
Inclusion Criteria: * Diagnosed with Knee OA according to ACR criteria. * Knee pain for more than 3 months. * Voluntary participation. Exclusion Criteria: * History of surgical intervention in the affected knee. * History of trauma to the affected knee within the last 6 months. * History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) or physical therapy involving the affected knee within the last 6 months. * Presence of severe psychiatric disorders such as severe depression, anxiety disorder, or psychosis. * Diagnosis of central nervous system diseases, including Parkinson's disease or multiple sclerosis. * Diagnosis of inflammatory arthritis, such as Rheumatoid Arthritis or Ankylosing Spondylitis. * Severe cognitive impairment. * Chronic decompensated cardiac, renal, or hepatic failure. * Severe psychiatric, neurological, or kognitive disorders. Decompensated cardiac, renal, or hepatic failure.
Contact & Investigator
Eser Kalaoglu, M.D.
PRINCIPAL INVESTIGATOR
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Frequently Asked Questions
Who can join the NCT07367126 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 70 Years, studying Knee Osteoarthristis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07367126 currently recruiting?
Yes, NCT07367126 is actively recruiting participants. Contact the research team at eserkalaoglu@hotmail.com for enrollment information.
Where is the NCT07367126 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07367126 clinical trial?
NCT07367126 is sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. The principal investigator is Eser Kalaoglu, M.D. at Istanbul Physical Medicine Rehabilitation Training and Research Hospital. The trial plans to enroll 102 participants.