NCT06527287 Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)
| NCT ID | NCT06527287 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Womack Army Medical Center |
| Condition | Chronic Ankle Instability |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2025-10-13 |
| Primary Completion | 2027-06-14 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 180 participants in total. It began in 2025-10-13 with a primary completion date of 2027-06-14.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to examine the effectiveness of a novel ankle rehabilitation protocol on improving clinical and health outcomes in physically active individuals with chronic ankle instability (CAI). Our central hypothesis is NATION, a novel rehabilitation intervention that includes neurocognitive tasks, will improve overall health and function, and reduce lower extremity musculoskeletal injury in physically active individuals with CAI.
Eligibility Criteria
Inclusion Criteria: * Physically active and engage in regular exercise/training * 18-44 years old (accounts for 86% of the individuals deployed in recent military conflicts) * Answer "yes" to Question 1 (i.e., have you ever sprained an ankle?) on the Ankle Instability Instrument * Answer "yes" to any four of the remaining Ankle Instability Instrument questions * Score \<24 on the Cumberland Ankle Instability Tool * Report at least two episodes of the ankle "giving way" in the last six months * Access to a functional email address and internet for completion of health and Service member outcomes * Ability to provide informed consent Exclusion Criteria: * Unable to read or comprehend the English language. * An ankle sprain within the last six (≤6) weeks that resulted in altered or missed physical activity for one or more (≥1) consecutive days. * History of ankle surgery. * History of lower extremity fracture in the last year or history of fracture that required fixation. * Any peripheral neuropathies or other health conditions/current musculoskeletal injuries that may influence balance. * Pregnant females (will be eligible for participation in the study after delivery of the baby and medical clearance by a qualified and licensed healthcare provider).
Contact & Investigator
Megan H Roach
PRINCIPAL INVESTIGATOR
Womack Army Medical Center
Frequently Asked Questions
Who can join the NCT06527287 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 44 Years, studying Chronic Ankle Instability. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06527287 currently recruiting?
Yes, NCT06527287 is actively recruiting participants. Contact the research team at megan.h.roach.civ@health.mil for enrollment information.
Where is the NCT06527287 trial being conducted?
This trial is being conducted at Lexington, United States, Fort Bragg, United States.
Who is sponsoring the NCT06527287 clinical trial?
NCT06527287 is sponsored by Womack Army Medical Center. The principal investigator is Megan H Roach at Womack Army Medical Center. The trial plans to enroll 180 participants.