NCT04917068 Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa
| NCT ID | NCT04917068 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Minnesota |
| Condition | Bulimia Nervosa |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2022-04-01 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2022-04-01 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN). The research will investigate neural and psychological anticipatory processes in BN, both in the scanner and the natural environment.
Eligibility Criteria
Inclusion Criteria: Bulimia nervosa (BN) and healthy control (HC) groups: * Right-handed * Ability to read and speak in English BN group only: * Eating Disorder Examination (EDE) diagnosis of BN (i.e., at least one objective bulimic episode and one self-induced vomiting episode per week for at three months) with binge episodes always accompanied by self-induced vomiting * Stable dose for at least 6 weeks of any recent changes in medication impacting mood, appetite, or weight HC group only: * No binge eating or purging episodes for the past three months on the EDE * No current or past history of an eating disorder as diagnosed by Structured Clinical Interview for DSM-5 Disorders Exclusion Criteria: * History of gastric bypass surgery * Medical condition acutely affecting eating behavior and/or weight (i.e., pregnancy, lactation, thyroid disease) * Current medical or psychiatric instability (i.e., hospitalization required in the past three months) * Lifetime history of psychosis or bipolar disorder * History of neurological disorder or injury (i.e., stoke, head injury with \>10 minutes loss of consciousness) * Current substance use disorder * BMI less than 19 kg/m\^2 * Acute suicidality requiring hospitalization * fMRI exclusions as specifiedd by the Center for Magnetic Resonance Research * Food allergy that cannot be accommodated through substitutions to the laboratory test snack
Contact & Investigator
Carol B Peterson, PhD
PRINCIPAL INVESTIGATOR
University of Minnesota Department of Psychiatry and Behavioral Sciences
Frequently Asked Questions
Who can join the NCT04917068 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 55 Years, studying Bulimia Nervosa. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04917068 currently recruiting?
Yes, NCT04917068 is actively recruiting participants. Contact the research team at peter161@umn.edu for enrollment information.
Where is the NCT04917068 trial being conducted?
This trial is being conducted at Minneapolis, United States.
Who is sponsoring the NCT04917068 clinical trial?
NCT04917068 is sponsored by University of Minnesota. The principal investigator is Carol B Peterson, PhD at University of Minnesota Department of Psychiatry and Behavioral Sciences. The trial plans to enroll 100 participants.