NCT05377125 Neural Mechanisms of Response Inhibition Training for OCRD
| NCT ID | NCT05377125 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Wisconsin, Milwaukee |
| Condition | Obsessive-Compulsive Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 118 participants |
| Start Date | 2022-12-22 |
| Primary Completion | 2027-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 118 participants in total. It began in 2022-12-22 with a primary completion date of 2027-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.
Eligibility Criteria
Inclusion Criteria: * age between 18 and 60 * moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7) * a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD) * estimated IQ \> 80 * presence of a RI deficits (SSRT ≥ 215ms). Exclusion Criteria: * Current substance use disorder * Severe ADHD * Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia * Current psychotherapy * Change in psychotropic medication status within 8 weeks before the study or during the study * Use of stimulant medication * Active suicidal risk * Contraindications for MRI procedures
Contact & Investigator
Hanjoo Lee, Ph.D.
PRINCIPAL INVESTIGATOR
University of Wisconsin, Milwaukee
Frequently Asked Questions
Who can join the NCT05377125 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Obsessive-Compulsive Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05377125 currently recruiting?
Yes, NCT05377125 is actively recruiting participants. Contact the research team at leehj@uwm.edu for enrollment information.
Where is the NCT05377125 trial being conducted?
This trial is being conducted at Milwaukee, United States.
Who is sponsoring the NCT05377125 clinical trial?
NCT05377125 is sponsored by University of Wisconsin, Milwaukee. The principal investigator is Hanjoo Lee, Ph.D. at University of Wisconsin, Milwaukee. The trial plans to enroll 118 participants.