NCT06074614 Neural Control of Breathing in Parkinson's Disease
| NCT ID | NCT06074614 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Radboud University Medical Center |
| Condition | Parkinson Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2023-10-30 |
| Primary Completion | 2025-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2023-10-30 with a primary completion date of 2025-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Breathing is a complex process, which can be controlled through voluntary command or neural control. Parkinson's disease (PD) is a progressive neurological disorder. Many individuals with PD experience respiratory problems, such as coughing difficulties or shortness of breath. Changes in neural control of breathing could be part of the reason of these respiratory problems. This study will measure whether neural control of breathing is impaired in individuals with PD compared to healthy individuals.
Eligibility Criteria
Inclusion Criteria: * Healthy subjects: competent adult (\>18 years) volunteers * Patients: adult (\<18 years) patients with Parkinson's disease, clinically confirmed by a movement disorder specialised neurologist with Hoehn and Yahr staging 1 to 3 * Willingness and ability to understand nature and content of the study * Ability to participate and comply with study requirements Exclusion Criteria: * Healthy subjects: previous or ongoing diseases of the central nervous system * Patients: previous or ongoing diseases of the central nervous system, other than Parkinson's disease * History of or current psychiatric treatment * History of or current brain surgery or epilepsy, unclusing deep brain stimulation * Neuromuscular disorders * Pre-existing pulmonary disease, such as chronic obstructive pulmonary disease, asthma or pulmonary fibrosis * TMS incompatibility (metal parts in head or neck, skin allergies) * Implanted cardiac pacemaker or defibrillator, neurostimulator, cochlear implant or medical infusion device * Large or ferromagnetic metal parts in the head (exept for a dental wire) * Pregnancy * Smoking
Contact & Investigator
Jonne Doorduin, PhD
PRINCIPAL INVESTIGATOR
Radboud University Medical Center
Frequently Asked Questions
Who can join the NCT06074614 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Parkinson Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06074614 currently recruiting?
Yes, NCT06074614 is actively recruiting participants. Contact the research team at jonne.doorduin@radboudumc.nl for enrollment information.
Where is the NCT06074614 trial being conducted?
This trial is being conducted at Nijmegen, Netherlands.
Who is sponsoring the NCT06074614 clinical trial?
NCT06074614 is sponsored by Radboud University Medical Center. The principal investigator is Jonne Doorduin, PhD at Radboud University Medical Center. The trial plans to enroll 30 participants.
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