Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
Trial Parameters
Brief Summary
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand: 1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
Eligibility Criteria
Inclusion Criteria: * Signed Informed Consent Form * Age between 18 and 60 years * BMI 30-50 kg/m2 * Knowledge of German, which requires sufficient written and allow oral patient education Inclusion criteria for initially healthy group * Blood pressure \< 140/90 mmHg * Normal glucose metabolism * HbA1c \< 6.5 % * Fasting Glucose \< 7.0 mmol/l * Normal lipid metabolism o LDL-cholesterol \< 5.0 mmol/l * ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference) * TG \> 1.7 mmol/l * HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female) * Fasting glucose ≥ 5.6 mmol/l * BP ≥ 130/85 mmHg Exclusion Criteria: * Pregnancy * Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies * History of or planned bariatric operation * Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases) * Active Malignant tumor (\<2a remission)