NCT06778070 National Program to Overcome Pelvic Pain studY (POPPY)
| NCT ID | NCT06778070 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, San Francisco |
| Condition | Chronic Pelvic Pain Syndrome (CPPS) |
| Study Type | INTERVENTIONAL |
| Enrollment | 220 participants |
| Start Date | 2025-05-12 |
| Primary Completion | 2029-01-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 220 participants in total. It began in 2025-05-12 with a primary completion date of 2029-01-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A randomized, parallel-group, investigator-blinded, comparative effectiveness trial of a fully remote, videoconference-based pelvic floor yoga program versus a physical conditioning program for women with chronic pelvic pain syndrome.
Eligibility Criteria
Inclusion Criteria: * Women (individuals reporting female sex assigned at birth who self-identify as women or non-binary) aged 18 years or older * Report chronic or recurrent pain in the pelvis (between or below the anterior iliac crests) for at least 6 months * Report at least moderate pain intensity based on a screening pain log * Report prior clinical evaluation of their pelvic pain by a healthcare professional including at least a superficial pelvic exam * Willing to refrain from initiating new clinical treatments that may affect their pain during the study period Exclusion Criteria: * Report pelvic pain occurring exclusively with menses or exclusively during sexual intercourse (although candidates with at least some pain between menses or intercourse are still eligible) * Participation in organized yoga classes or muscle strengthening programs (e.g., Pilates) in the past 4 weeks, or any prior yoga therapy specifically directed at pelvic pain * Lacking technical requirements to complete intervention classes by video, including no access to broadband internet or a Zoom-compatible device larger than a smartphone \[display screen at least 7 inches in diagonal\] (although the study team may loan devices to participants from underrepresented backgrounds) * Currently pregnant (by self-report or screening test), pregnant within the past 12 weeks, or planning pregnancy during the study period * Diagnosed with an alternate, reversible cause of pelvic pain that is unlikely to respond to yoga and requires another treatment modality (e.g., current pelvic infection or a gynecologic dermatosis) * Surgery or irradiation to the genital or pelvic structures within the past 12 weeks, or anticipating upcoming surgery or irradiation to these structures during the study period * Initiation, dose escalation, or weaning of pharmacologic agents that may affect pelvic pain severity in the past 4 weeks, such as analgesics, antidepressants, or anticonvulsants-(however, women on stable doses of these medications for at least 4 weeks will still be eligible) * Use of formal psychological therapies specifically for pelvic pain (e.g., systematic desensitization, cognitive therapy, relaxation therapy) within 4 weeks of screening, or plans to engage in these therapies during the study period * Unable to walk up a flight of stairs or at least 2 blocks on level ground (i.e., functional capacity \< 4 METs), or unable to get up from a supine to a standing position without assistance * Participation in another interventional study that might interfere with or confound study procedures, or known conflict with multiple upcoming study intervention class dates * Inability to understand the informed consent form or fill out questionnaires or complete study interviews * Any other serious physical or mental issue that, in the opinion of the investigators, would interfere with study participation (e.g., advanced dementia, uncontrolled substance use or serious mental illness, life expectancy \<6 months)
Contact & Investigator
Alison Huang, MD
PRINCIPAL INVESTIGATOR
University of California, San Francisco
Frequently Asked Questions
Who can join the NCT06778070 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Chronic Pelvic Pain Syndrome (CPPS). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06778070 currently recruiting?
Yes, NCT06778070 is actively recruiting participants. Contact the research team at Alison.Huang@ucsf.edu for enrollment information.
Where is the NCT06778070 trial being conducted?
This trial is being conducted at San Francisco, United States.
Who is sponsoring the NCT06778070 clinical trial?
NCT06778070 is sponsored by University of California, San Francisco. The principal investigator is Alison Huang, MD at University of California, San Francisco. The trial plans to enroll 220 participants.