NCT07531498 Muscle Aging Phenotypes in Childhood Cancer Survivors
| NCT ID | NCT07531498 |
| Status | Recruiting |
| Phase | — |
| Sponsor | St. Jude Children's Research Hospital |
| Condition | Muscle Weakness |
| Study Type | OBSERVATIONAL |
| Enrollment | 533 participants |
| Start Date | 2026-10-01 |
| Primary Completion | 2030-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 533 participants in total. It began in 2026-10-01 with a primary completion date of 2030-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distinct muscle health endotypes in adult survivors of childhood cancer using advanced imaging, neuromuscular testing, and functional assessment. Survivors with reduced muscle health and community controls will undergo multimodal magnetic resonance imaging and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing during a single study visit integrated into an ongoing cohort evaluation. Identifying mechanistic endotypes of impaired muscle health will support development of targeted interventions to preserve function and improve long-term outcomes in childhood cancer survivors. Primary Objective: \- Characterize reduced muscle health endotypes in childhood cancer survivors. Secondary Objective: \- Identify specific treatment and lifestyle related risk factors for each reduced muscle health endotype. Exploratory Objective: \- Host germline genetics will be associated with specific muscle endotypes.
Eligibility Criteria
Inclusion Criteria: * Age 18 years old or older at time of consent and enrolled in SJLIFE. * Participant (100 per group for a total of 400) is/has: * Group 1: No cancer history * Group 2: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND exposure to a peripheral neurotoxin. * Group 3: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND NOT exposed to a peripheral neurotoxin. * Group 4: Age and sex specific relative lean mass z-score of less than -0.5 AND age and sex specific hand grip strength or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 REGARDLESS of exposure status. * Participant or legal guardian is able and willing to give informed consent. Exclusion Criteria: * Presence of implanted medical devices or metal that would interfere with MRI or MRS. * Female Participant is pregnant. * Body weight exceeding 300 pounds, due to MRI restrictions. * Inability to lie flat on his/her back for 90 minutes or longer for MRI. * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent. * Presence of known radiation-induced nerve injury. * Prescence of pre-existing neurologic (non-cancer related) or who develop chronic neurologic disorders (i.e. Charcot Marie Tooth Disease, Downs, congenital brain injury). * Participation on a lifestyle or medication clinical trial within the past 1 year.
Contact & Investigator
Kirsten Ness, PhD
PRINCIPAL INVESTIGATOR
St. Jude Children's Research Hospital
Frequently Asked Questions
Who can join the NCT07531498 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Muscle Weakness. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07531498 currently recruiting?
Yes, NCT07531498 is actively recruiting participants. Contact the research team at referralinfo@stjude.org for enrollment information.
Where is the NCT07531498 trial being conducted?
This trial is being conducted at Memphis, United States.
Who is sponsoring the NCT07531498 clinical trial?
NCT07531498 is sponsored by St. Jude Children's Research Hospital. The principal investigator is Kirsten Ness, PhD at St. Jude Children's Research Hospital. The trial plans to enroll 533 participants.