NCT07347821 Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty
| NCT ID | NCT07347821 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of Warsaw |
| Condition | Total Hip Arthroplasty (THA) |
| Study Type | OBSERVATIONAL |
| Enrollment | 1,000 participants |
| Start Date | 2025-11-22 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 1,000 participants in total. It began in 2025-11-22 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is: Are selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?
Eligibility Criteria
Inclusion Criteria: * 18 years old and more * patient qualified for primary TKA or primary THA * patient diagnosed with hip or knee osteoarthritis * a complete set of tissues of good quality and volume is available * does not meet the exclusion criteria. Exclusion Criteria: * lack of written consent to participate in the study or surgery * any private or professional relationship with the Investigators * genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others) * genetic metabolic diseases (e.g., gout and others) * genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others) * previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others) * patients undergoing revision after THA/TKA * autoimmune diseases in the patient's medical history * traumatic injury to the hip or knee joint * previous participation in the study.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07347821 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Total Hip Arthroplasty (THA). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07347821 currently recruiting?
Yes, NCT07347821 is actively recruiting participants. Contact the research team at artur.stolarczyk@wum.edu.pl for enrollment information.
Where is the NCT07347821 trial being conducted?
This trial is being conducted at Ostrów Mazowiecka, Poland.
Who is sponsoring the NCT07347821 clinical trial?
NCT07347821 is sponsored by Medical University of Warsaw. The trial plans to enroll 1,000 participants.