Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms
Trial Parameters
Brief Summary
This project aims to study the benefits of probiotics namely Bifidobacterium infantis YLGB-1496 in modulating gut microbiota of children with respiratory symptoms, among pre-school children in Malaysia aged \>12 months old, \<7 years old.
Eligibility Criteria
Inclusion Criteria: * Preschool children (\>12 months old, \<7 years old). * Having respiratory symptoms (having at least two of the following signs and symptoms: fever (even if only reported not measured), nasal obstruction, chills, sore throat, headache, cough, runny nose, olfactory disturbances, or taste disturbances; Pucarelli-Lebreiro et al., 2022). * Healthy with current weight of P20-P80 percentile chart of children * Infant formula powder does not contain probiotics; prebiotics FOS is not allowed, GOS \<2g/ 100g is allowed * Willing to commit throughout the experiment Exclusion Criteria: * Long term medication \>6 months for any diseases * Deformity * Mothers with metabolic and/or chronic diseases * Current or previous diseases, conditions or interventions that may interfere with the study (such as tolerance and/or growth and development), such as gastrointestinal malformations, chronic diarrhea, malabsorption syndromes, malnutrition, congenital immunodeficiency or surgery * Or