NCT07657624 Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
| NCT ID | NCT07657624 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Beijing Anzhen Hospital |
| Condition | Coronary Heart Disease |
| Study Type | OBSERVATIONAL |
| Enrollment | 2,352 participants |
| Start Date | 2025-06-30 |
| Primary Completion | 2031-05-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 2,352 participants in total. It began in 2025-06-30 with a primary completion date of 2031-05-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. Diagnosis of coronary heart disease (meeting at least one of the following): * Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery; * Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment; * Objective evidence of myocardial ischemia or typical clinical symptoms 3. Completion of standardized neuropsychological assessment during hospitalization 4. Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments 5. Provision of signed written informed consent Exclusion Criteria: 1. Previously diagnosed dementia. 2. History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment. 3. Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder). 4. Pregnancy or breastfeeding.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07657624 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Coronary Heart Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07657624 currently recruiting?
Yes, NCT07657624 is actively recruiting participants. Contact the research team at tcc2033@163.com for enrollment information.
Where is the NCT07657624 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07657624 clinical trial?
NCT07657624 is sponsored by Beijing Anzhen Hospital. The trial plans to enroll 2,352 participants.