NCT05020626 Modelling Tau Distribution From DTI With Generative Adversarial Network for Alzheimer's Disease Diagnosis
| NCT ID | NCT05020626 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Chinese University of Hong Kong |
| Condition | Alzheimer's Disease Diagnosis |
| Study Type | OBSERVATIONAL |
| Enrollment | 250 participants |
| Start Date | 2021-06-30 |
| Primary Completion | 2025-06-29 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 250 participants in total. It began in 2021-06-30 with a primary completion date of 2025-06-29.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The most significant impact of this project is to propose for the first time a novel generative adversarial network (GAN), as one kind of deep learning architecture, to automatically generate synthetic PET images reflecting tau deposition, from brain DTI images. If successful, this framework will become the most state-of-the-art approach to simulate the stereotypical pattern of intracerebral tau accumulation and distribution in vivo. Synthetic tau-PET images via DTI, possessing overwhelming superiority in radiation-free, non-invasiveness and cost-effectiveness, will potentially serve as one of alternative modalities of PET in detecting tau-load and probably outperform PET on accessibility, generalizability, and availability in future, making it much more attractive in clinical application. A big conceptual shift may occur preferring a fire-new tau-PET simulated via DTI. The DTI data-driven deep learning framework to be created in this project will constitute an accurate, robust, clinically applicable and explainable tool to efficiently categorize the subjects into tau-burden positive and tau-burden negative cases, which will undoubtedly contribute to both clinical and research activities.
Eligibility Criteria
Inclusion Criteria: * With the age of 55 years and above * With brain MRI taken within ±6 months from the date of clinically confirmed diagnosis of AD, MCI or normal cognition. Exclusion Criteria: * AD with mixed dementia * Non-AD dementia * History of severe traumatic brain injury, severe depression, stroke, brain tumors, and incident major systemic illness
Frequently Asked Questions
Who can join the NCT05020626 clinical trial?
This trial is open to participants of all sexes, aged 55 Years or older, studying Alzheimer's Disease Diagnosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05020626 currently recruiting?
Yes, NCT05020626 is actively recruiting participants. Visit ClinicalTrials.gov or contact Chinese University of Hong Kong to inquire about joining.
Where is the NCT05020626 trial being conducted?
This trial is being conducted at Hong Kong, Hong Kong.
Who is sponsoring the NCT05020626 clinical trial?
NCT05020626 is sponsored by Chinese University of Hong Kong. The trial plans to enroll 250 participants.
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