NCT06479837 Modeling Host-Pathogen Interaction Using Lymphoid Organoids
| NCT ID | NCT06479837 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Condition | Staphylococcal Infections |
| Study Type | OBSERVATIONAL |
| Enrollment | 500 participants |
| Start Date | 2026-09-17 |
| Primary Completion | 2043-12-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 500 participants in total. It began in 2026-09-17 with a primary completion date of 2043-12-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S. aureus interacts with a person s cells to cause infections in the spine. Objective: To learn how S. aureus interacts with cells in the body using tissues from tonsils discarded after standard surgery to remove them. Eligibility: People aged 2 years and older who are scheduled to have their tonsils removed. Design: Researchers will select participants for the study based on review of their existing medical records, including results of blood tests; any imaging scans, including x-rays; and reports about tissue specimens. Participants will answer questionnaires about their health and past infections. They can do this online or on paper. Participants will collect a nasal swab 1 week before their surgery. They will be given a tool that looks like a long cotton swab. They will twirl it around inside their nose. The swab will pick up cells and fluids that will be used for research. After their surgery, the participant s surgeon will save samples of tonsil tissue. The surgeon will send these tissue samples and the nasal swab to researchers at the NIH. These tissues and the swab will be used in studies to help researchers understand how S. aureus interacts with cells in the body. They hope these studies will help them find better ways to treat S. aureus infections.
Eligibility Criteria
* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all of the following criteria: * Aged \>=2 yrs. * Undergoing tonsillectomy as part of their clinical care. * Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 yrs). * Willing to allow samples and data to be stored and shared for future secondary research. * Willing to allow future genetic testing on their biospecimens. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Active infection. * Active tonsilitis. * Pregnant. * Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications. * Current or past intravenous drug use. * Any condition that, in the judgment of the investigator, may put the participant at undue risk or make them unsuitable for participation in the study
Contact & Investigator
Michael Otto, M.D.
PRINCIPAL INVESTIGATOR
National Institute of Allergy and Infectious Diseases (NIAID)
Frequently Asked Questions
Who can join the NCT06479837 clinical trial?
This trial is open to participants of all sexes, aged 2 Years or older, up to 120 Years, studying Staphylococcal Infections. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06479837 currently recruiting?
Yes, NCT06479837 is actively recruiting participants. Contact the research team at katherine.le@nih.gov for enrollment information.
Where is the NCT06479837 trial being conducted?
This trial is being conducted at Bethesda, United States, Bethesda, United States.
Who is sponsoring the NCT06479837 clinical trial?
NCT06479837 is sponsored by National Institute of Allergy and Infectious Diseases (NIAID). The principal investigator is Michael Otto, M.D. at National Institute of Allergy and Infectious Diseases (NIAID). The trial plans to enroll 500 participants.