NCT06023472 Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing
| NCT ID | NCT06023472 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Professor Ernest Hung-Yu Ng |
| Condition | Infertility |
| Study Type | INTERVENTIONAL |
| Enrollment | 318 participants |
| Start Date | 2024-11-01 |
| Primary Completion | 2027-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 318 participants in total. It began in 2024-11-01 with a primary completion date of 2027-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups in a 1:1 ratio : (1) the microfluidic chip group and (2) the density gradient centrifugation group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as the standard practice of the Centre. Both women and clinicians will be blinded from the group allocation i.e. a double blind study.
Eligibility Criteria
Inclusion Criteria: * Women aged \<43 years at the time of ovarian stimulation for IVF * Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy * Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation Exclusion Criteria: * Use of frozen semen for insemination * Use of donor oocytes and spermatozoa * Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated; * Women who had been recruited into this study before and * Women joining other randomized trials
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06023472 clinical trial?
This trial is open to participants of all sexes, up to 43 Years, studying Infertility. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06023472 currently recruiting?
Yes, NCT06023472 is actively recruiting participants. Contact the research team at ptong@connect.hku.hk for enrollment information.
Where is the NCT06023472 trial being conducted?
This trial is being conducted at Hong Kong, China.
Who is sponsoring the NCT06023472 clinical trial?
NCT06023472 is sponsored by Professor Ernest Hung-Yu Ng. The trial plans to enroll 318 participants.