Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters
Trial Parameters
Brief Summary
Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high. Semen quality can affect IVF outcomes, and the current method used to process semen can damage the sperm and DNA. Scientists are now testing a new method called microfluidic chip technology, which reduces DNA damage and increases sperm movement. This study will compare the effectiveness of the chip method and the current method on semen quality in men attending a fertility clinic. The study will randomly assign semen collected to one of the two methods and assess the semen quality using different tests, as well as the difference in using two different microfluidic chip platform . The primary outcome will be DNA fragmentation, and other outcomes include sperm count and motility. Semen samples would be collected from study subjects for analysis and that both the samples and results would not be used in patients' treatment.
Eligibility Criteria
Inclusion Criteria: * Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml. Exclusion Criteria: * Sperm concentration of the raw semen of less than 5 million motile sperm per ml * Men unable to provide an ejaculated semen sample