NCT05978947 Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters
| NCT ID | NCT05978947 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Professor Ernest Hung-Yu Ng |
| Condition | Infertility |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2023-07-01 |
| Primary Completion | 2025-03-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2023-07-01 with a primary completion date of 2025-03-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high. Semen quality can affect IVF outcomes, and the current method used to process semen can damage the sperm and DNA. Scientists are now testing a new method called microfluidic chip technology, which reduces DNA damage and increases sperm movement. This study will compare the effectiveness of the chip method and the current method on semen quality in men attending a fertility clinic. The study will randomly assign semen collected to one of the two methods and assess the semen quality using different tests, as well as the difference in using two different microfluidic chip platform . The primary outcome will be DNA fragmentation, and other outcomes include sperm count and motility. Semen samples would be collected from study subjects for analysis and that both the samples and results would not be used in patients' treatment.
Eligibility Criteria
Inclusion Criteria: * Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml. Exclusion Criteria: * Sperm concentration of the raw semen of less than 5 million motile sperm per ml * Men unable to provide an ejaculated semen sample
Contact & Investigator
Frequently Asked Questions
Who can join the NCT05978947 clinical trial?
This trial is open to male participants only, studying Infertility. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05978947 currently recruiting?
Yes, NCT05978947 is actively recruiting participants. Contact the research team at ptong@connect.hku.hk for enrollment information.
Where is the NCT05978947 trial being conducted?
This trial is being conducted at Hong Kong, China.
Who is sponsoring the NCT05978947 clinical trial?
NCT05978947 is sponsored by Professor Ernest Hung-Yu Ng. The trial plans to enroll 80 participants.