Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility
Trial Parameters
Brief Summary
The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility. Researchers will utilize an ultrasound multimodal system to systematically assess endometrial parameters, including thickness, morphology, peristalsis, and blood flow indices. The study aims to enroll approximately 300 infertile women aged 20 to 45 years. Participants will be observed and grouped based on whether they receive anticoagulant medications, such as aspirin or heparin sodium, as part of their standard clinical care. The study will track ultrasound-based receptivity indicators and follow up on pregnancy status and outcomes at 45 and 90 days of gestation. This study is purely observational, and all clinical treatment decisions are made independently of the study protocol.
Eligibility Criteria
Inclusion Criteria: * Female patients aged 20 to 45 years. Clinically diagnosed with infertility and planning to undergo embryo transfer or monitored conception cycles. Patients who have complete baseline clinical data and are willing to undergo multimodal ultrasound evaluation of endometrial receptivity during the window of implantation. Voluntarily agreed to participate in this observational study and signed the informed consent form for data collection. Exclusion Criteria: * Presence of congenital uterine malformations (e.g., septate uterus, bicornuate uterus, unicornuate uterus) that significantly alter the endometrial cavity. Presence of untreated severe intrauterine lesions, such as submucosal fibroids, severe intrauterine adhesions, or endometrial polyps that may mechanically interfere with implantation. Severe underlying systemic diseases, including but not limited to severe liver or kidney dysfunction, or malignant tumors. Known severe bleeding disorders or strict contraindica