NCT07266103 Mechanistic Study of Personalized rTMS in Chronic Pain
| NCT ID | NCT07266103 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Aalborg University |
| Condition | Chronic Pain |
| Study Type | INTERVENTIONAL |
| Enrollment | 90 participants |
| Start Date | 2026-03-01 |
| Primary Completion | 2027-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 90 participants in total. It began in 2026-03-01 with a primary completion date of 2027-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Previous research has demonstrated that repetitive magnetic brain stimulation can be an effective adjunctive treatment for several conditions, including chronic pain. However, current stimulation protocols are typically standardized and do not account for individual variability in brain function. This uniform, one-size-fits-all approach results in only about 40% of patients experiencing meaningful clinical benefit, while the remainder show little to no improvement. To address this limitation, the present study will investigate how magnetic stimulation can be tailored to individuals with chronic pain. By analyzing each participant's brain signals prior to treatment, we aim to personalize stimulation parameters to better match individual neural characteristics and potentially enhance therapeutic outcomes. The design of this study builds directly on the findings of a previous clinical trial.
Eligibility Criteria
Inclusion Criteria: * Presence of chronic pain (present most of the days for more than 3 months). * Pain with a mean pain intensity between 3-9 on a 0-10 pain scale (where 0 means no pain and 10 means the worst pain imaginable). * Speak and understand English or Danish Exclusion Criteria: * Pregnant or breastfeeding * Current uncontrolled major depression as the main diagnosis * Current history of substance abuse * Lack of ability to cooperate, to fully understand the protocol or any difficulty in filling out questionnaires (e.g., due to language or cognitive problems) * Formal contraindications to TMS application (presence of epilepsy, cranial implanted ferromagnetic devices, e.g., intracranial neurostimulator or cochlear implants, tattoos with metal ink on the face or permanent make up with metal in the face ) * Unable to answer the "Transcranial Magnetic Stimulation Adult Safety Screen" screening questionnaire. * Participation in other research protocols within 1 month before the inclusion.
Contact & Investigator
Enrico De Martino
PRINCIPAL INVESTIGATOR
Aalborg University
Frequently Asked Questions
Who can join the NCT07266103 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Chronic Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07266103 currently recruiting?
Yes, NCT07266103 is actively recruiting participants. Contact the research team at edm@hst.aau.dk for enrollment information.
Where is the NCT07266103 trial being conducted?
This trial is being conducted at Gistrup, Denmark.
Who is sponsoring the NCT07266103 clinical trial?
NCT07266103 is sponsored by Aalborg University. The principal investigator is Enrico De Martino at Aalborg University. The trial plans to enroll 90 participants.
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