NCT03398369 Mechanistic Clinical Trial of Advanced Imaging for CRT
| NCT ID | NCT03398369 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Virginia |
| Condition | Heart Failure, Systolic |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2018-01-05 |
| Primary Completion | 2025-01-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 180 participants in total. It began in 2018-01-05 with a primary completion date of 2025-01-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
Eligibility Criteria
Inclusion Criteria: 1. Chronic systolic HF 2. LVEF 35% or less 3. Guideline-based class I or II indication for CRT Exclusion Criteria: 1. Inability to provide informed consent 2. Pregnancy 3. Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging 4. Cerebral aneurysm clips 5. Cochlear implants 6. Other metallic implants known to be contraindications to CMR (does not include pacemakers and ICDs) 7. Severe claustrophobia 8. Acute kidney injury 9. Acute renal failure or chronic kidney disease with GFR \< 45 cc/min/1.73m2 10. Liver transplant 11. Gadolinium allergy 12. \>10% premature ventricular contraction (PVC) burden; and 13) estimated \>10% atrial fibrillation (AF) burden based on available clinical data.
Contact & Investigator
Kenneth C Bilchick, MD
PRINCIPAL INVESTIGATOR
University of Virginia Health System
Frequently Asked Questions
Who can join the NCT03398369 clinical trial?
This trial is open to participants of all sexes, aged 20 Years or older, up to 90 Years, studying Heart Failure, Systolic. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03398369 currently recruiting?
Yes, NCT03398369 is actively recruiting participants. Contact the research team at bilchick@virginia.edu for enrollment information.
Where is the NCT03398369 trial being conducted?
This trial is being conducted at Charlottesville, United States.
Who is sponsoring the NCT03398369 clinical trial?
NCT03398369 is sponsored by University of Virginia. The principal investigator is Kenneth C Bilchick, MD at University of Virginia Health System. The trial plans to enroll 180 participants.
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