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Recruiting NCT03806283

Mechanisms of Pregnancy Vascular Adaptations

Trial Parameters

Condition Pre-Eclampsia
Sponsor University of Wisconsin, Madison
Study Type OBSERVATIONAL
Phase N/A
Enrollment 166
Sex FEMALE
Min Age 18 Years
Max Age 40 Years
Start Date 2018-11-20
Completion 2027-04
Interventions
Omental Biopsy

Brief Summary

The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.

Eligibility Criteria

Inclusion Criteria: * Female * Ages 18 to 40 years old * Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent * Undergoing caesarean section, either planned or otherwise with or without trial of labor Exclusion Criteria: * Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia. * Any major fetal structural anomalies or aneuploidies * Undergoing cesarean section for placental abruption or bleeding complications. * Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)

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