NCT06951100 Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
| NCT ID | NCT06951100 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Edinburgh |
| Condition | Atrial Fibrillation (AF) |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2025-05-01 |
| Primary Completion | 2026-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2025-05-01 with a primary completion date of 2026-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)
Eligibility Criteria
Inclusion Criteria: 1. Age 18 years and over 2. Primary presentation with symptoms related to atrial fibrillation 3. Atrial fibrillation with a ventricular rate \>100 bpm on a 12-lead electrocardiogram 4. Able to provide informed consent Exclusion Criteria 1. Previous myocardial infarction 2. Previous coronary revascularisation procedure 3. Patients in renal failure (eGFR \<30ml/min/1.73m2) or major allergy to contrast media 4. Pregnancy or breast feeding 5. Deemed unsuitable for participation in the study by the attending clinician 6. Previous enrolment in the trial
Frequently Asked Questions
Who can join the NCT06951100 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Atrial Fibrillation (AF). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06951100 currently recruiting?
Yes, NCT06951100 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of Edinburgh to inquire about joining.
Where is the NCT06951100 trial being conducted?
This trial is being conducted at Edinburgh, United Kingdom.
Who is sponsoring the NCT06951100 clinical trial?
NCT06951100 is sponsored by University of Edinburgh. The trial plans to enroll 300 participants.
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