NCT07454135 Mechanisms of Atrial Pathoelectrophysiology in HCM
| NCT ID | NCT07454135 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust |
| Condition | Hypertrophic Cardiomyopathy (HCM) |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2026-05-26 |
| Primary Completion | 2027-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2026-05-26 with a primary completion date of 2027-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual. Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them. The information from this study may help improve future treatments for people who have both HCM and AF.
Eligibility Criteria
Inclusion Criteria: * Paroxysmal or persistent atrial fibrillation * Diagnosis of hypertrophic cardiomyopathy * Patient planning to proceed to atrial fibrillation ablation following clinical consultation * Age 18-80 years * Able and willing to provide written informed consent * Able and willing to comply with study follow up requirements Exclusion Criteria: * Any clinical contra-indication to ablation * Any disease limiting life expectancy to \<1 year * Potential participant currently pregnant or breast feeding * Contraindication to MRI including renal dysfunction (eGFR\<30ml/min) * Unable to understand verbal or written explanations given in English
Frequently Asked Questions
Who can join the NCT07454135 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Hypertrophic Cardiomyopathy (HCM). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07454135 currently recruiting?
Yes, NCT07454135 is actively recruiting participants. Visit ClinicalTrials.gov or contact Guy's and St Thomas' NHS Foundation Trust to inquire about joining.
Where is the NCT07454135 trial being conducted?
This trial is being conducted at London, United Kingdom.
Who is sponsoring the NCT07454135 clinical trial?
NCT07454135 is sponsored by Guy's and St Thomas' NHS Foundation Trust. The trial plans to enroll 40 participants.