NCT06372444 Mechanisms of Acute Kidney Injury in Severe Infections
| NCT ID | NCT06372444 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Uppsala University Hospital |
| Condition | Sepsis |
| Study Type | OBSERVATIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-05-01 |
| Primary Completion | 2026-04-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 15 participants in total. It began in 2024-05-01 with a primary completion date of 2026-04-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Eligibility Criteria
Inclusion Criteria: Patients with sepsis and AKI * \> 30 years * At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination Healthy volunteers * \> 30 years * No previously known kidney disease * Normal plasma creatinine value Exclusion Criteria: * Chronic renal failure (CKD stage \>3a) or dialysis * Instability in vital functions that makes PET-CT examination unsuitable * Claustrophobia or other reasons that make the patient unable to lie still during the examination. * Pregnancy and breastfeeding
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06372444 clinical trial?
This trial is open to participants of all sexes, aged 30 Years or older, studying Sepsis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06372444 currently recruiting?
Yes, NCT06372444 is actively recruiting participants. Contact the research team at miklos.lipcsey@uu.se for enrollment information.
Where is the NCT06372444 trial being conducted?
This trial is being conducted at Uppsala, Sweden.
Who is sponsoring the NCT06372444 clinical trial?
NCT06372444 is sponsored by Uppsala University Hospital. The trial plans to enroll 15 participants.