NCT06372444 Mechanisms of Acute Kidney Injury in Severe Infections
| NCT ID | NCT06372444 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Uppsala University Hospital |
| Condition | Sepsis |
| Study Type | OBSERVATIONAL |
| Enrollment | 15 participants |
| Start Date | 2024-05-01 |
| Primary Completion | 2026-04-03 |
Trial Parameters
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Brief Summary
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Eligibility Criteria
Inclusion Criteria: Patients with sepsis and AKI * \> 30 years * At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination Healthy volunteers * \> 30 years * No previously known kidney disease * Normal plasma creatinine value Exclusion Criteria: * Chronic renal failure (CKD stage \>3a) or dialysis * Instability in vital functions that makes PET-CT examination unsuitable * Claustrophobia or other reasons that make the patient unable to lie still during the examination. * Pregnancy and breastfeeding