NCT06598150 Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke
| NCT ID | NCT06598150 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Northwestern University |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 32 participants |
| Start Date | 2023-05-20 |
| Primary Completion | 2026-08-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 32 participants in total. It began in 2023-05-20 with a primary completion date of 2026-08-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.
Eligibility Criteria
Inclusion Criteria: * Adults aged at least 18y * Able to perform shoulder abduction task (confirmed during screening and initial examination) * Safe to undergo MRI * Able to follow visual instructions using MRI-compatible vision correction goggles * No brainstem or cerebellar lesions * No severe concurrent medical problems * Cognitive/attentional capacity to focus on a task * Able to communicate in English or Spanish Additional inclusion criteria for stroke participants: * Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project * Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45). Exclusion Criteria: * MRI contraindications * Severe claustrophobia * Pregnant women * Prisoners * Vulnerable populations * Diagnosis/history of: * multiple sclerosis * brain tumor * brain radiation * traumatic brain injury * dementia * Parkinson's disease * Concurrent enrollment in an intervention study * Concurrent use of medications known to suppress central nervous system activity
Contact & Investigator
Molly G Bright, DPhil
PRINCIPAL INVESTIGATOR
Northwestern University
Frequently Asked Questions
Who can join the NCT06598150 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06598150 currently recruiting?
Yes, NCT06598150 is actively recruiting participants. Contact the research team at anvil@northwestern.edu for enrollment information.
Where is the NCT06598150 trial being conducted?
This trial is being conducted at Chicago, United States.
Who is sponsoring the NCT06598150 clinical trial?
NCT06598150 is sponsored by Northwestern University. The principal investigator is Molly G Bright, DPhil at Northwestern University. The trial plans to enroll 32 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.