Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
Trial Parameters
Brief Summary
A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients from the Mass General Brigham Electronic Data Warehouse (EDW), who will then be randomized into either the manual review arm or the AI-assisted review arm.
Eligibility Criteria
Inclusion Criteria: * Documented diagnosis of heart failure (e.g., ICD-9 codes 428 ICD-10 codes I50 or Problem list in the electronic health record) * Most recent left ventricular ejection fraction (LVEF) assessed within the past 24 months * Seen Mass General Brigham provider within the last 24 months Exclusion Criteria: * LVEF \<50% currently prescribed or intolerant to an evidence-based beta-blocker, ARNI, MRA, and SGLT2i at least 50% goal dose * LVEF\>50% currently prescribed or intolerant to SGLT2i * Systolic blood pressure (SBP) \<90 mmHg at last measure