NCT07874035 Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
| NCT ID | NCT07874035 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ahmed Adel Ahmed Elsayed Ali Radwan |
| Condition | Colorectal Cancer Survivors |
| Study Type | INTERVENTIONAL |
| Enrollment | 54 participants |
| Start Date | 2026-05-17 |
| Primary Completion | 2027-08-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 54 participants in total. It began in 2026-05-17 with a primary completion date of 2027-08-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
PURPOSE: To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. BACKGROUND: Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited. HYPOTHESES: It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. RESEARCH QUESTION: Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
Eligibility Criteria
Inclusion Criteria: 1. Colorectal cancer with probable sarcopenia. 2. Age 40-59 years. 3. Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (\>15 seconds without upper limb support). 4. Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability. 5. Medical clearance for supervised exercise. 6. Ability to follow instructions and complete assessments. Exclusion Criteria: 1. Any contraindication to resistance or blood flow restriction training. 2. Uncontrolled cardiovascular disease or hypertension. 3. Recent thromboembolic events. 4. Severe peripheral vascular disease. 5. Uncontrolled treatment-related complications, such as severe anemia or infection. 6. Metastatic bone disease in the lower limbs. 7. Neurological or musculoskeletal disorders limiting safe participation.
Frequently Asked Questions
Who can join the NCT07874035 clinical trial?
This trial is open to participants of all sexes, aged 40 Years or older, up to 59 Years, studying Colorectal Cancer Survivors. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07874035 currently recruiting?
Yes, NCT07874035 is actively recruiting participants. Visit ClinicalTrials.gov or contact Ahmed Adel Ahmed Elsayed Ali Radwan to inquire about joining.
Where is the NCT07874035 trial being conducted?
This trial is being conducted at Cairo, Egypt.
Who is sponsoring the NCT07874035 clinical trial?
NCT07874035 is sponsored by Ahmed Adel Ahmed Elsayed Ali Radwan. The trial plans to enroll 54 participants.
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