NCT07675603 Low-carbohydrate Diet and Low-Density Lipoprotein - Cholesterol (LDL-c) Interindividual Variability
| NCT ID | NCT07675603 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Bath |
| Condition | Healthy |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-02-05 |
| Primary Completion | 2027-03 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-02-05 with a primary completion date of 2027-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Ketogenic diets are very low-carbohydrate diets that increase hepatic production of ketone bodies, which have several effects as substrates and signals. Ketogenic diets are used to manage some conditions (e.g., drug-resistant epilepsy), and their potential for managing many other conditions (e.g., cancer) is being actively explored. Indeed, the British Dietetic Association acknowledge the potential for ketogenic diets to improve glycaemic control to a greater extent than some other diets in people with type 2 diabetes. A lower fasting glucose is also relevant to future mortality in people without diabetes. Ketogenic diets are popular in the general population, with up to 15% of the UK following a low-carbohydrate diet. There is, therefore, great interest in ketogenic diets amongst people with and without health conditions. However, although the diet shows promising results in improving blood sugar levels, it has also shown to increase low-density lipoprotein-cholesterol (LDL-c) in some individuals, which has been linked to increased cardiovascular health risks. The aim of this project is to find the potential for personalised use of (or guidance to avoid) ketogenic diets for cardiovascular disease risk. To do that the investigators will ask participants to replicate 24 hours of a ketogenic diet and a control diet thrice each. This will allow the investigators to find variability between responses and have a better idea of individuals who could benefit (or not) from following the ketogenic diet.
Eligibility Criteria
Inclusion Criteria: * Age: \>18 years * Body mass index: 18.5-35 kg·m-2 * Low-Density Lipoprotein-cholesterol \<4.9 mmol/L * Non-fasting triglycerides \<2.3 mmol/L Exclusion Criteria: * weight instability (\>5% change in body mass within last 3 months) * smoker * diagnosis of hypercholesterolaemia or any other lipid-related disease * diagnosis of diabetes * diagnosis of atherosclerotic cardiovascular disease * elevated fasting glucose (\>5.4 mmol/L) * dietary intolerances or allergies or to other study procedures * diagnosis of gastrointestinal disorders * any other condition/medication that could introduce bias to the study * already following a ketogenic diet * not willing to follow a ketogenic diet * unable to understand English language
Contact & Investigator
Javier Gonzalez, PhD
PRINCIPAL INVESTIGATOR
University of Bath
Frequently Asked Questions
Who can join the NCT07675603 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Healthy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07675603 currently recruiting?
Yes, NCT07675603 is actively recruiting participants. Contact the research team at bs954@bath.ac.uk for enrollment information.
Where is the NCT07675603 trial being conducted?
This trial is being conducted at Bath, United Kingdom.
Who is sponsoring the NCT07675603 clinical trial?
NCT07675603 is sponsored by University of Bath. The principal investigator is Javier Gonzalez, PhD at University of Bath. The trial plans to enroll 20 participants.