| NCT ID | NCT07449000 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universidad Autonoma de Nuevo Leon |
| Condition | Corneal Scarring Fibrosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 46 participants |
| Start Date | 2026-02-12 |
| Primary Completion | 2027-02-11 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 46 participants in total. It began in 2026-02-12 with a primary completion date of 2027-02-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry, corneal aberrations and corneal scarring severity in adult patients with corneal scars of different etiologies. Participants will be randomly assigned to receive either topical losartan 0.8 mg/mL or placebo eyedrops 6 times per day for six months.
Eligibility Criteria
* Inclusion Criteria: * Adults aged 18 years or older * Presence of corneal scar with a duration of at least 1 month * Corneal scars of any etiology * Corneal scars with or without corneal neovascularization * Stable corneal scar without epithelial defect * No active treatment for the underlying condition for at least 1 month * Exclusion Criteria: * Refusal or inability to provide written informed consent * Presence of corneal epithelial defect or friable epithelium * Age under 18 years * Pregnancy * Known allergy or hypersensitivity to losartan
Contact & Investigator
Karim Mohamed-Noriega, Dr. med.
PRINCIPAL INVESTIGATOR
Universidad Autonoma de Nuevo Leon
Frequently Asked Questions
Who can join the NCT07449000 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Corneal Scarring Fibrosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07449000 currently recruiting?
Yes, NCT07449000 is actively recruiting participants. Contact the research team at karim.mohamednrg@uanl.edu.mx for enrollment information.
Where is the NCT07449000 trial being conducted?
This trial is being conducted at Monterrey, Mexico.
Who is sponsoring the NCT07449000 clinical trial?
NCT07449000 is sponsored by Universidad Autonoma de Nuevo Leon. The principal investigator is Karim Mohamed-Noriega, Dr. med. at Universidad Autonoma de Nuevo Leon. The trial plans to enroll 46 participants.