Trial Parameters
Brief Summary
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
Eligibility Criteria
Inclusion Criteria: * Willing and able to provide informed consent * Aged 18-50 years * Score of or below 45 on the Dimensional Anhedonia Rating Scale (DARS; Rizvi et al., 2015) * Sufficient written and spoken English skills to understand what the study involves, and to complete the questionnaires * Non- or light-smoker (5 cigarettes a day) Exclusion Criteria: * Past or present DSM-5 axis-I diagnosis (based on SCID results at screening) other than anxiety disorder, dysthymia or unipolar depression * First-degree family member with severe psychiatric illness * CNS-medication last 6 weeks (including as part of another study) * Current blood pressure or other heart medication (especially aliskiren or beta blockers) * Diagnosis of intravascular fluid depletion or dehydration * History of angioedema * Impaired kidney function (based on self-report) * Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised condition