NCT06183632 Lipid Characterisation of Plasma Microparticles in a Large Population of Healthy Donors
| NCT ID | NCT06183632 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Condition | Healthy Donor |
| Study Type | OBSERVATIONAL |
| Enrollment | 150 participants |
| Start Date | 2024-01-25 |
| Primary Completion | 2029-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 150 participants in total. It began in 2024-01-25 with a primary completion date of 2029-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Extracellular vesicles (EVs) are membrane structures containing numerous mediators categorised according to their size and mode of production. Among them, microparticles (MPs) are EVs between 100 nm and 1 μm in size that are produced by budding at the plasma membrane of different cell types following different mechanisms of cell activation or death. MPs include a large pool of bioactive molecules, such as lipids, proteins or nucleic acids. This makes them important mediators of intercellular communication, increasingly recognised for their role in various biological processes such as inflammation, coagulation, immune response and tumour progression. Their ability to transmit molecular signals between cells may have implications for disease pathogenesis and cellular interactions in pathological microenvironments. These MPs therefore appear to be an innovative biomarker, potentially useful in the early management of disease, both in terms of diagnosis and as a therapeutic target. The main techniques used to analyse these MPs include flow cytometry, which enables surface markers to be quantified and determined, and electron microscopy, which provides a direct view of their morphology and structure. Molecular biology, such as the quantitative PCR technique, is also an approach used by several teams, notably to search for RNA or DNA fragments involved in various biological processes. However, few studies have focused on the lipid composition of these MPs. Since MPs are membrane vesicles, they are a major lipid reservoir. In addition, lipids represent a significant population of molecules with extensive properties, whether in inflammation, cell proliferation, energy metabolism, etc. The aim of this project is to develop a reliable and robust method for analysing plasma MP concentration, phenotype and lipid composition in a population of healthy volunteers. These parameters will subsequently provide a comparator for studying MPs in populations of patients suffering from cardiovascular and/or inflammatory diseases.
Eligibility Criteria
Inclusion Criteria: * Person who has given his/her non-opposition * All healthy volunteers are eligible to donate according to EFS criteria. Exclusion Criteria: * Person subject to a legal protection measure (curatorship, guardianship, etc) * Pregnant, parturient or breast-feeding women * Adults who are incapable or unable to give their consent * Minors * Person not eligible to donate according to EFS criteria.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06183632 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Healthy Donor. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06183632 currently recruiting?
Yes, NCT06183632 is actively recruiting participants. Contact the research team at Damien.leleu@chu-dijon.fr for enrollment information.
Where is the NCT06183632 trial being conducted?
This trial is being conducted at Dijon, France.
Who is sponsoring the NCT06183632 clinical trial?
NCT06183632 is sponsored by Centre Hospitalier Universitaire Dijon. The trial plans to enroll 150 participants.