NCT06757491 Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea
| NCT ID | NCT06757491 |
| Status | Recruiting |
| Phase | — |
| Sponsor | The First Affiliated Hospital of Soochow University |
| Condition | Repetitive Transcranial Magnetic Stimulation |
| Study Type | INTERVENTIONAL |
| Enrollment | 42 participants |
| Start Date | 2024-08-01 |
| Primary Completion | 2025-12-25 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 42 participants in total. It began in 2024-08-01 with a primary completion date of 2025-12-25.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Objectives: To identify a central hub of visceral pain in IBS-D and elucidate the mechanism by which repetitive transcranial magnetic stimulation (rTMS) confers analgesic effects. Methods: A total of 42 IBS-D patients were recruited and randomly assigned (1:1) to the sham rTMS or the rTMS group. A nested cohort of 21 IBS-D participants who completed baseline fMRI assessments prior to randomization was included. Consistent with the randomization procedure，these individuals were evenly distributed between the two groups. Both participants and outcome assessors remained blinded to treatment allocation throughout the study. All patients completed the two-week intervention and were included in the final analysis.
Eligibility Criteria
All diagnoses were made by board-certified gastroenterologists. Eligible participants met the following inclusion criteria: (1) age between 18 and 75 years; (2) fulfillment of the Rome IV diagnostic criteria for IBS-D. Exclusion criteria included: (1) presence of inflammatory or other organic gastrointestinal diseases; (2) diagnosed psychiatric disorders; (3) history of anorectal, intestinal, or abdominal surgery; (4) pregnancy or lactation; (5) presence of metallic implants or cardiac pacemakers.
Contact & Investigator
Rui Li, Dr.
PRINCIPAL INVESTIGATOR
The First Affiliated Hospital of Soochow University
Frequently Asked Questions
Who can join the NCT06757491 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Repetitive Transcranial Magnetic Stimulation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06757491 currently recruiting?
Yes, NCT06757491 is actively recruiting participants. Contact the research team at wengruixia@suda.edu.cn for enrollment information.
Where is the NCT06757491 trial being conducted?
This trial is being conducted at Suzhou, China.
Who is sponsoring the NCT06757491 clinical trial?
NCT06757491 is sponsored by The First Affiliated Hospital of Soochow University. The principal investigator is Rui Li, Dr. at The First Affiliated Hospital of Soochow University. The trial plans to enroll 42 participants.