NCT07038408 Leave Nothing Behind Study Which Compares DCB With Bail Out BRS Versus BRS Strategy Alone

Eligibility & Interventions

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What to Expect as a Participant

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This trial targets 2,256 participants in total. It began in 2026-04-24 with a primary completion date of 2028-11-30.

Brief Summary

The goal of this study is to investigate the equivalence in early and long-term efficacy between the two "Leave nothing behind strategies" (Drug-Coated Baloon \[DCB\] strategy with bail-out BioResorbable Scaffold \[BRS\] versus BRS strategy) of de-novo native coronary artery lesions in a relatively young Percutaneous Coronary Intervention (PCI) population, to be more specific, Patients with Chronic Coronary Syndromes (CCS) and Acute Coronary Syndrome (ACS) (Non-ST-segment Elevation Myocardial Infarction \[NSTEMI\] and Unstable angina) between 18-68 years of age scheduled for PCI. The main questions aim to answer are: DCB strategy with bail-out BRS implantation has equivalent clinical outcomes at 12 months compared to BRS strategy? DCB strategy with bail-out BRS implantation has noninferior angiographic in-segment net gain at 13 months compared to BRS strategy? DCB strategy with bail-out BRS implantation has equivalent clinical outcomes at 60 months compared to BRS strategy? Participants will be followed at: 1. st FU visit - 1 month (in hospital) 2. nd FU visit - 6 months (telephone) 3. rd FU visit - 365 days±15 days (telephone) - 1Y Primary efficacy endpoint 4. th FU visit - 395 days±15 days (in hospital) co-primary efficacy endpoint for the angiographic substudy 5. th FU visit - 730 days±30 days (telephone call) - 2Y 6. th FU visit - 1095 days±30 days (telephone call) - 3Y 7. th FU visit - 1460 days±30 days (telephone call) - 4Y 8. th FU visit- 1825 days±30 days (telephone call) - 5Y

Eligibility Criteria

Inclusion Criteria: * Patients aged ≥ 18 years ≤ 68 years * Single vessel or multivessel disease with low to moderate complex de-novo native coronary artery lesions up to 30 mm length and reference vessel diameter 2.75-4.0 mm * Maximum of 3 target lesions * Maximal cumulative lesion length of all treated lesions 80 mm * Signed informed consent for participation in the study Exclusion Criteria: * ST-segment Elevation Myocardial Infarction (STEMI) treatment at index or in the previous 48 hours * Severe calcified lesions * Bifurcations lesions with planned 2 device strategy * Left-Main (LM) disease ≥ 50% diameter stenosis * More than 3 target lesions * Renal insufficiency with Glomerular Filtration Rate (GFR) \< 45 ml/min * Life expectancy less than 1 year * Known hypersensitivity or allergy to aspirin or P2Y12 receptor inhibitors * Incapable of providing written informed consent * Pregnant or breastfeeding women * Under judicial protection, tutorship, or curatorship * Participation in another trial

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