NCT06492967 LatAm-FINGERS Initiative for Cognitive Change
| NCT ID | NCT06492967 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia |
| Condition | Alzheimer Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,200 participants |
| Start Date | 2021-09-01 |
| Primary Completion | 2027-12-01 |
Trial Parameters
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Brief Summary
Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors. At the moment, there are no medications that halt the clinical expression of dementia. LatAm-FINGERS, a multicenter study across 12 Latin American countries, aims to study the feasibility of an intervention modifying lifestyle in individuals aged 60 to 77 at risk of dementia. Success could influence public policy on clinical care for older adults.
Eligibility Criteria
Inclusion Criteria * Age: 60-77 years. * Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) Risk Score \> 6. * Mini-Mental State Examination (MMSE) z score between 0 and -1.5 OR * CERAD Word List Learning Task (10 word x 3 repetitions) \< 0 z score OR * CERAD (delayed word list recall) \< z score \< 0 Exclusion Criteria * MMSE \< 20 * Dementia * Any medical condition that affects the participant's safety. * Severe osteoarticular problems that preclude the implementation of the physical activity intervention outlined in the protocol, such as, for example: osteoarthrosis of the knee(s), coxofemoral, or other. * Significant neurological disease, including dementia, cognitive impairment, Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis or history of significant head injury with persistent neurological sequelae or structural brain abnormalities, ma
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