L-theanine and Paraxanthine for Cognitive Improvement in Adults With ADHD and ASD
Trial Parameters
Brief Summary
This pilot study will test whether combining L-theanine and paraxanthine improves sustained attention, inhibitory control, and overall cognition in adults with ADHD and ASD. Two parallel randomized, single-blinded, repeated-measures crossover trials will be conducted. Participants will complete neuropsychological testing, fMRI scanning, and self-report measures following administration of the L-theanine-paraxanthine combination compared to placebo.
Eligibility Criteria
Inclusion Criteria: Adults (18+ years) diagnosed by a physician (per self-report) with ADHD or ASD \* Participants with a dual diagnosis and ASD and ADHD will be recruited but will only be included in the ASD group - their concurrent ADHD diagnosis will be included as an additional variable in exploratory analyses Exclusion Criteria: 1. Subjects with gross visual or auditory impairments that might limit their ability to perform neuropsychological tasks 2. Inability to read and follow written instructions 3. Physical, neurological, intellectual, or psychiatric impairments (except ADHD or ASD) that could affect cognitive and motor functions 4. Subjects on medications including antidepressants and antipsychotics that may affect performance in the tasks 5. Subjects on medications that are likely to interact with the administered substances, including regular intake of medication that could alter visual, auditory, cognitive, or motor functions (except stimulants) 6. History of head injury r